克罗米酚对男性高于促性腺素性功能减退症有效

纽约（法新社健康台湾版）1月初四日报道：据发表在12月初编辑出台湾版的《生育与不育》周刊的一项简报声称克罗米胺对部分较差促性腺素在性动态急剧下降的成年副作用有利。来自伯明翰阿拉巴马的学校的该简报的第一作者Scott J. Whitten助手在给与保险业新闻媒体采访谈起：“原发性或获得性HH副作用在给与侵害性大得多和更为昂贵的疗程（例如口服促性腺激素在类）前进行4个月初的克罗米胺试验性疗程是有利的。”Whitten助手和同事科学研究了克罗米胺对10名HH成年副作用（HH是导致成年不育的少见因素在）是不是直接。简报称克罗米胺疗程1年后，4名卡尔曼(氏)综合征副作用中只有一名副作用的体外溶解度减较差而全垂体动态急剧下降症副作用的体外缺乏副作用均没得到改善。相反，该简报声称3名成年发病的原发性HH成年副作用经过3个月初克罗米胺的疗程体外溶解度有了明显减较差。目前为止该组副作用已有两名恢复了后生。Whitten助手话说：“除非对克罗米胺疗程没反应，我们不会因为药物停止对副作用使用该药物。”最后作者总结话说：“因为状况受限制，对HH副作用促性腺激素在抗抑郁药和克罗米胺的随机科学研究难以进行，然而利用多系列的严苛选择标准化对副作用进行PG意味著帮助促使验证克罗米胺恢复成年较差后生的直接性。 Male Hypogonadotropic Hypogonadism May Respond to Clomiphene CitrateBy Will Boggs, MDNEW YORK (Reuters Health) Jan 04 - Some men with hypogonadotropic hypogonadism (HH) benefit from treatment with clomiphene citrate, according to a report in the December issue of Fertility and Sterility.Patients with idiopathic or acquired HH "may benefit from a 4-month trial (of clomiphene citrate) before proceeding with more invasive and expensive therapies, such as injectable gonadotropins," lead author Dr. Scott J. Whitten, from University of Alabama at Birmingham, told Reuters Health.Dr. Whitten and colleagues investigated whether 10 men with HH, a rare cause of male infertility, might respond to treatment with clomiphene citrate.Only one of four patients with Kallmann's syndrome experienced an improvement in sperm concentration after 1 year of therapy with clomiphene citrate, the authors report, and no patient with panhypopituitarism experienced a reversal of azoospermia with clomiphene citrate treatment.In contrast, all three men with -onset idiopathic HH experienced significant increases in sperm concentrations and testosterone levels after 3 months of therapy with clomiphene citrate, the report indicates. Two pregnancies he been achieved in this subgroup so far."We did not he any of our patients discontinue the clomiphene because of side effects, only if there was lack of response," Dr. Whitten said."Because this is such a rare condition, additional randomized studies comparing gonadotropins with clomiphene in this subtype of HH patients would be difficult to perform," the authors conclude. "However, larger series using strict inclusion criteria for stratifying patients may be helpful to further examine the success of clomiphene treatment in restoration of this form of male subfertility."Fertil Steril 2006;86:1664-1668.

编辑：蓝色幻想

编辑： 张靖